Difference between revisions of "IRF2BP2"
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Latest revision as of 14:34, 26 January 2018
IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) is a Protein Coding gene.
Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Action
IRF2BP2 interacts with the C-terminal transcriptional repression domain of IRF2.
Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities.
Represses the NFAT1-dependent transactivation of NFAT-responsive promoters.
Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle[1].
Northern blot analysis revealed high levels of IRF2BP2 mRNA in adult human heart and skeletal muscles, but immunoblot analysis showed low levels of IRF2BP2 protein in skeletal muscle, indicating post-transcriptional regulation of IRF2BP2 expression [1].
IRF2BP2 protein levels are markedly increased by ischemia in skeletal and cardiac muscle compared to normoxic controls. IRF2BP2 is a novel ischemia-induced coactivator of VEGFA expression that may contribute to revascularization of ischemic cardiac and skeletal muscles[1].
Pathways
... todo
Diseases
Diseases associated with IRF2BP2 include Mesenchymal Chondrosarcoma and Common Variable Immunodeficiency.
References
- Error fetching PMID 20702774:
Expression
Upregulated - mainly after 1 hour after exercise.
Coregulation
| Gene | SIAH2 | MNT | WBP1L | BHLHE40 | SLC25A25 | ELMSAN1 | PIP5K1C | ARID5B | CTGF | KLF11 | CX3CL1 | LRRC8A |
| r | 0.7785532 | 0.7768744 | 0.7723620 | 0.7699279 | 0.7516998 | 0.7476651 | 0.7470779 | 0.7165333 | 0.7135609 | 0.7129015 | 0.7070233 | 0.7015876 |
