IRF2BP2
IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) is a Protein Coding gene.
Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Action
IRF2BP2 interacts with the C-terminal transcriptional repression domain of IRF2.
Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities.
Represses the NFAT1-dependent transactivation of NFAT-responsive promoters.
Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle[1].
Northern blot analysis revealed high levels of IRF2BP2 mRNA in adult human heart and skeletal muscles, but immunoblot analysis showed low levels of IRF2BP2 protein in skeletal muscle, indicating post-transcriptional regulation of IRF2BP2 expression [1].
IRF2BP2 protein levels are markedly increased by ischemia in skeletal and cardiac muscle compared to normoxic controls. IRF2BP2 is a novel ischemia-induced coactivator of VEGFA expression that may contribute to revascularization of ischemic cardiac and skeletal muscles[1].
Pathways
... todo
Diseases
Diseases associated with IRF2BP2 include Mesenchymal Chondrosarcoma and Common Variable Immunodeficiency.
References
- Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, and Stewart AF. IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression. FASEB J. 2010 Dec;24(12):4825-34. DOI:10.1096/fj.10-167049 |
Expression
Upregulated - mainly after 1 hour after exercise.
Coregulation
| Gene | SIAH2 | MNT | WBP1L | BHLHE40 | SLC25A25 | ELMSAN1 | PIP5K1C | ARID5B | CTGF | KLF11 | CX3CL1 | LRRC8A |
| r | 0.7785532 | 0.7768744 | 0.7723620 | 0.7699279 | 0.7516998 | 0.7476651 | 0.7470779 | 0.7165333 | 0.7135609 | 0.7129015 | 0.7070233 | 0.7015876 |
