TPM4
Tropomyosin alpha-4 chain
Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments.
Multiple transcript variants encoding different isoforms have been found for this gene.
Contents
Action
Binds to actin filaments in muscle and non-muscle cells.
Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction.
Provides stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament.
Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity).
Binds calcium (PubMed:1836432)
Pathways
Diseases
Inflammatory Myofibroblastic Tumor, Autosomal Dominant Macrothrombocytopenia.
Expression
Upregulated - after 1 hour after exercises.
