SERPINH1
Serpin H1 Synonim: 47 kDa heat shock protein
Member of the serpin superfamily of serine proteinase inhibitors.
Contents
Action
Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
The change of HSP47, collagen specific molecular chaperone, expression in rat skeletal muscle may regulate collagen production with gravitational conditions[1].
The gravity-regulated HSP47 may play a role in the maintenance of the extracellular matrix by modulating collagen production at the primary stage of adaptation[2]..
HSP47 may be involved in the repair or regeneration of muscle fibers in addition to the fibrotic change in the connective tissue[3].
Pathways
Diseases
Osteogenesis Imperfecta, Type X and Preterm Premature Rupture Of The Membranes
References
- Oguro A, Sakurai T, Okuno M, Nagata K, and Atomi Y. The change of HSP47, collagen specific molecular chaperone, expression in rat skeletal muscle may regulate collagen production with gravitational conditions. Biol Sci Space. 2004 Nov;18(3):150-1.
- Oguro A, Sakurai T, Fujita Y, Lee S, Kubota H, Nagata K, and Atomi Y. The molecular chaperone HSP47 rapidly senses gravitational changes in myoblasts. Genes Cells. 2006 Nov;11(11):1253-65. DOI:10.1111/j.1365-2443.2006.01021.x |
- Higuchi I, Hashiguchi A, Matsuura E, Higashi K, Shiraishi T, Hirata N, Arimura K, and Osame M. Different pattern of HSP47 expression in skeletal muscle of patients with neuromuscular diseases. Neuromuscul Disord. 2007 Mar;17(3):221-6. DOI:10.1016/j.nmd.2006.11.008 |
Expression
Upregulated - after 1 hour after exercises and after training.
Hsp47 mRNA levels in cultured myoblasts increased significantly with hypergravity treatment at 40G for 2 h, and decreased with microgravity treatment at almost 0G for 1-2 h. Collagen mRNA levels were also altered, although changes were slower and less pronounced compared with those for HSP47. [3].
