NDRG1
N-Myc Downstream Regulated 1.
It belongs to the alpha/beta hydrolase superfamily.
Contents
Action
Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis.
Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath.
Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking.
Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.
This gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation.
The mTORC2 substrate, phosphorylated protein kinase C α (PKCα), and the mTORC2 activity readout, phosphorylated N-myc downstream regulated 1 (NDRG1) protein increased with running in Ric WT mice, but were not altered by running in Ric mKO muscle.
Pathways
The mammalian target of rapamycin complex 2 (mTORC2) is an important regulator of muscle glucose uptake in response to insulin stimulation.
p-NDRG1 T346 and p-mTOR S2481 have been characterized and used as in vivo markers of mTORC2 activity[1]
SGK1 phosphorylates NDRG1 at three residues, T346, T356 and T366 It has been suggested that the phosphorylations of these residues are excellent surrogates of mTORC2 activity. Thus, p-NDRG1 T346 has been widely used in this capacity of an mTORC2 biomarker[1].
Diseases
Charcot-Marie-Tooth Disease, Type 4D and Congenital Hypomyelination Neuropathy
References
- Kleinert M, Parker BL, Fritzen AM, Knudsen JR, Jensen TE, Kjøbsted R, Sylow L, Ruegg M, James DE, and Richter EA. Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice. J Physiol. 2017 Jul 15;595(14):4845-4855. DOI:10.1113/JP274203 |
Expression
Upregulated - after 1 hour after exercises.
