Dynamics of deactivation

For model validation, recovery dynamics, ATP, ADP, AMP, PCr, glycolysis, oxidative phosphorylation Ver. 1.0.

Recovery dynamics: ATP, ADP, AMP, PCr

Figure from (Li et al., 2009) [1], Recovery dynamics for ATP, ADP, AMP (model)

Figure from (Coccimiglio et al., 2020) [2], Recovery dynamics for PCr, ATP, ADP, AMP (model)

Figure from (Bartlett et al., 2020) [3], Changes in intramuscular ATP during the 240 s trial and 10 minutes of recovery. A slow ATP recovery rate is probably caused by a decrease in the total pool of adenine nucleotides associated with the formation of IMP and the excretion of its metabolites, see (Sahlin & Broberg, 1990) [4].

Figure from (Chen et al., 1999) [5], Recovery dynamics for cytosolic ADP after exercise.

Figure from (Fiedler et al., 2016) [6], Recovery dynamics for PCr and pH after exercise at 40% maximum voluntary contraction (MVC)

Figure from (Fiedler et al., 2016) [6], Recovery dynamics for ADP and ATP synthesis rates during and after exercise at 40% maximum voluntary contraction (MVC)

Table from (Hellsten et al., 1999) [7], Skeletal muscle concentrations of adenine nucleotides. AMP is decreased at the end of the exercise compared to rest, while AMP free is increased. At the same time, IMP rises, perhaps that is why AMP decreases (?)

Dynamics of glycolysis after cessation of exercise

Figure from (Schmitz et al., 2010) [8], HMP recovery dynamics. “First, we performed high time resolution dynamic in vivo measurements of the turnover of phosphorylated glycolytic metabolites (hexose monophosphates; HMP) in human leg muscle after exhaustive exercise using 31P NMR spectroscopy. Next, the Lambeth & Kushmerick computational model of glycolysis in muscle was used as a platform to investigate if current knowledge of glycolytic flux and concentration control incorporated in the model was sufficient to explain the measured HMP dynamics (Lambeth & Kushmerick, 2002)”.

Figure from (Crowther et al., 2002) [9], Time course of glycolytic flux rate in human muscle at the end of and after an exercise bout.

Dynamics of muscle VO2 recovery after cessation of exercise

Figure from (Behnke et al., 2009) [10], The time course of muscle VO2 recovery from contractions (i.e., muscle VO2 off-kinetics).

Figure from (Cannon et al., 2014) [11], The time course of muscle VO2 during and after cessation of exercise.

References

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2. Coccimiglio IF and Clarke DC. ADP is the dominant controller of AMP-activated protein kinase activity dynamics in skeletal muscle during exercise. PLoS Comput Biol. 2020 Jul;16(7):e1008079. DOI:10.1371/journal.pcbi.1008079 |
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