WorkingNotes

Working Notes

Working notes on modeling the processes on metabolic, signaling and gene expression regulation levels in human skeletal muscle during an exercise

The major challenge facing us is incredibly complex and cannot be comprehensively resolved at this time. But any interesting research challenge must be a little crazy.

The working notes: A roadmap of the Model development. Link...

Data quality assessment

One of the side effects of the modeling is the indirect assessment of data quality in various subject areas. Our exploration of relevant numerical data reveals that even relatively well-studied fields lack enough suitable qualitative and quantitative data required for model construction, fitting and validation. Therefore, modeling process is useful not only as a tool to build applied computational models but also as an indirect way to assess the quality of available data.

Compared to the outstanding issues, the amount of suitable data available to date suggests that a fairly complete model will be at least 90% hypothetical. Such a model cannot be truly validated. Its adequacy can only be confirmed by the general behaviour of the known variables/indicators.

The working notes: The summary of data problems for modeling. Link...

The working notes: The summary of protein localization data problems. Link...

The working notes: AMPK localization, open questions. Link...

The working notes: Data for fitting, problems, Different pH dynamics in MRS studies and pH measurements using biopsy, different La dynamics. Link...

The working notes: Results obtained using a mechanistic approach to finding the X-factor for PGC-1α. Link...

The working notes: Potential causes of temporary shifts in the expression of genes after exercise. Link...

These notes will be updated according to our review of new published data on these topics