WorkingNotes

WorkingNotes

Working notes on modeling the processes in human skeletal muscle during exercise

The main task arising before us is incredibly complex and cannot be fully resolved at this time. But an interesting challenge must be a little crazy.

The working notes: A roadmap of the Model development. Link...

Data quality assessment

One of the side effects of modeling is the indirect assessment of data quality in various subject areas. A search for relevant numerical data reveals that even relatively well-studied areas lack enough suitable data, despite hundreds of studies. Therefore, modeling is useful not only as a tool for creating applied models but also as an indirect tool for assessing the available data quality.

Compared to the outstanding issues, the amount of suitable data available to date suggests that a fairly complete model will be at least 90% hypothetical. Such a model cannot be truly validated. Its adequacy can only be confirmed by the general behaviour of the known variables/indicators.

The working notes: The summary of data problems for modeling. Link...

The working notes: The summary of protein localization data problems. Link...

The working notes: AMPK localization, open questions. Link...

The working notes: Data for fitting, problems, Different pH dynamics in MRS studies and when measuring pH using biopsy, different La dynamics. Link...

The working notes: Results obtained using a mechanistic approach to finding the X-factor for PGC-1α. Link...

The working notes: The possible causes of temporary shifts in the genes expression after exercise. Link...

These notes will be updated as the rest of the files will be translated and formatted