Difference between revisions of "GCH1"
From Muscle
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Revision as of 09:48, 26 January 2018
This gene encodes a member of the GTP cyclohydrolase family.
Contents
Action
The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate.
BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases.
GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
May modify pain sensitivity and persistence [1].
Pathways
eNOS activation
Diseases
Hyperphenylalaninemia, Bh4-Deficient, B and Dystonia, Dopa-Responsive, With Or Without Hyperphenylalaninemia.
References
Error fetching PMID 24373571:
- Error fetching PMID 24373571:
Expression
Upregulated - after 1 hour after exercises.
