Difference between revisions of "CNN2"
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Latest revision as of 18:24, 26 January 2018
Calponin 2.
Alternative splicing results in multiple transcript variants encoding different isoforms.
Contents
Action
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction.
The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
It is capable of binding to actin, calmodulin, troponin C and tropomyosin.
May function in the structural organization of actin filaments.
It could play a role in smooth muscle contraction and cell adhesion.
Pathways
Cytoskeleton tension regulates the transcription of CNN2 gene and the degradation of calponin 2 protein [1].
Regulated by transcriptional factor HES-1 (hairy and enhancer of split 1) in the 5′-upstream region of mouse Cnn2 promoter (Jiang et al., 2014)[1].
Deletion or mutation of the HES-1 site in mouse Cnn2 promoter abolished the mechanical regulation and resulted in a substrate stiffness independent high level of transcriptional activity. Therefore, the regulatory mechanism is via a low tension-induced repression of transcription.
Corresponding to the down-regulation of Cnn2 gene expression, the level of HES-1 increased in cells cultured on soft gel substrates in comparison with that in cells cultured on hard gels (Jiang et al., 2014). HES-1 is known to function downstream of the Notch-RBP J signaling pathway (Kageyama et al., 1997), which has been suggested to mediate cellular mechanoregulations (Morrow et al., 2005; Morrow et al., 2007). [1].
Diseases
References
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Expression
Upregulated - after 1 hour after exercises.
