IRF2BP2 - Revision history

Fedor at 07:34, 26 January 2018

2018-01-26T07:34:39Z

Fedor at 02:25, 26 January 2018

2018-01-26T02:25:34Z

Fedor at 10:56, 23 January 2018

2018-01-23T10:56:40Z

Fedor: Created page with "IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) is a Protein Coding gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms...."

2018-01-23T10:53:36Z

Created page with "IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) is a Protein Coding gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms...."

New page

IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) is a Protein Coding gene.

Alternative splicing results in multiple transcript variants encoding distinct isoforms.

====Action====
IRF2BP2 interacts with the C-terminal transcriptional repression domain of IRF2.

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities.

Represses the NFAT1-dependent transactivation of NFAT-responsive promoters.

Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle.

====Diseases====
Diseases associated with IRF2BP2 include Mesenchymal Chondrosarcoma and Common Variable Immunodeficiency.

====Expression====
Upregulated - mainly after 1 hour after exercise.

[[File:IRF2BP2.png|IRF2BP2 expression]]

====Coregulation====
{| class="wikitable"
|Gene
|SIAH2
|MNT
|WBP1L
|BHLHE40
|SLC25A25
|ELMSAN1
|PIP5K1C
|ARID5B
|CTGF
|KLF11
|CX3CL1
|LRRC8A
|-
|r
|0.7785532
|0.7768744
|0.7723620
|0.7699279
|0.7516998
|0.7476651
|0.7470779
|0.7165333
|0.7135609
|0.7129015
|0.7070233
|0.7015876
|}

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	\|0.7015876		\|0.7015876
	\|}		\|}
		+
		+	[[Category:muscle_DEGs]]

← Older revision		Revision as of 10:56, 23 January 2018
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	Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle.		Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle.
		+
		+	====Pathways====
		+	... todo

	====Diseases====		====Diseases====

@@ Line 10: / Line 10: @@
 Represses the NFAT1-dependent transactivation of NFAT-responsive promoters.
-Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle.
+Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle<cite>1</cite>.
 ====Pathways====
@@ Line 17: / Line 23: @@
 ====Diseases====
 Diseases associated with IRF2BP2 include Mesenchymal Chondrosarcoma and Common Variable Immunodeficiency.
 ====Expression====