Fedor: Created page with "Calponin 2. Alternative splicing results in multiple transcript variants encoding different isoforms. Calponin ====Action==== Thin filament-associated protein that is..."

2018-01-26T11:24:21Z

Created page with "Calponin 2. Alternative splicing results in multiple transcript variants encoding different isoforms. Calponin ====Action==== Thin filament-associated protein that is..."

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Calponin 2.

Alternative splicing results in multiple transcript variants encoding different isoforms.

[[Calponin]]

====Action====
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction.

The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

It is capable of binding to actin, calmodulin, troponin C and tropomyosin.

May function in the structural organization of actin filaments.

It could play a role in smooth muscle contraction and cell adhesion.

====Pathways====
Cytoskeleton tension regulates the transcription of CNN2 gene and the degradation of calponin 2 protein <cite>1</cite>.

Regulated by transcriptional factor HES-1 (hairy and enhancer of split 1) in the 5′-upstream region of mouse Cnn2 promoter (Jiang et al., 2014)<cite>1</cite>.

Deletion or mutation of the HES-1 site in mouse Cnn2 promoter abolished the mechanical regulation and resulted in a substrate stiffness independent high level of transcriptional activity.
Therefore, the regulatory mechanism is via a low tension-induced repression of transcription.

Corresponding to the down-regulation of Cnn2 gene expression, the level of HES-1 increased in cells cultured on soft gel substrates in comparison with that in cells cultured on hard gels (Jiang et al., 2014).
HES-1 is known to function downstream of the Notch-RBP J signaling pathway (Kageyama et al., 1997), which has been suggested to mediate cellular mechanoregulations (Morrow et al., 2005; Morrow et al., 2007).
<cite>1</cite>.

====Diseases====

====References====
<biblio>
#1 pmid=26970176
#2 pmid=2500984
</biblio>

====Expression====
Upregulated - after 1 hour after exercises.

[[File:CNN2.png|CNN2 expression]]

[[Category:muscle_DEGs]]
[[Category:Calponin]]

CNN2 - Revision history

Fedor: Created page with "Calponin 2. Alternative splicing results in multiple transcript variants encoding different isoforms. Calponin ====Action==== Thin filament-associated protein that is..."